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Proper activation of MafA is required for optimal differentiation and maturation of pancreatic β-cells

A key therapeutic approach for the treatment of Type 1 diabetes (T1D) is transplantation of functional islet β-cells. Despite recent advances in generating stem cell-derived glucose-responsive insulin(+) cells, their further maturation to fully functional adult β-cells still remains a daunting task....

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Pubblicato in:Best Pract Res Clin Endocrinol Metab
Autori principali: El Khattabi, Ilham, Sharma, Arun
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4690007/
https://ncbi.nlm.nih.gov/pubmed/26696512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.beem.2015.09.006
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