IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington disease

Aging is a major risk factor for the progression of neurodegenerative diseases, including Huntington disease (HD). Reduced neuronal IGF1 or Irs2 signaling have been shown to extend life span in mice. To determine whether Irs2 signaling modulates neurodegeneration in HD, we genetically modulated Irs2...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Sadagurski, Marianna, Cheng, Zhiyong, Rozzo, Aldo, Palazzolo, Isabella, Kelley, Gregory R., Dong, Xiaocheng, Krainc, Dimitri, White, Morris F.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 2011
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195462/
https://ncbi.nlm.nih.gov/pubmed/21926467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI46305
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