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Over-expression of the catalytic core of mitochondrial DNA (mtDNA) polymerase in the nervous system of Drosophila melanogaster reduces median life span by inducing mtDNA depletion

DNA polymerase γ (pol γ) is the sole DNA polymerase devoted to mitochondrial DNA (mtDNA) replication. We have characterized the molecular and physiological effects of over-expression of the catalytic subunit of pol γ, pol γ-α, in the nervous system of Drosophila melanogaster using the upstream activ...

詳細記述

保存先:
書誌詳細
出版年:J Neurochem
主要な著者: Martínez-Azorín, Francisco, Calleja, Manuel, Hernández-Sierra, Rosana, Farr, Carol L., Kaguni, Laurie S., Garesse, Rafael
フォーマット: Artigo
言語:Inglês
出版事項: 2007
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4853903/
https://ncbi.nlm.nih.gov/pubmed/17999718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2007.05122.x
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