Reduced Stimulation of Recombinant DNA Polymerase γ and Mitochondrial DNA (mtDNA) Helicase by Variants of Mitochondrial Single-stranded DNA-binding Protein (mtSSB) Correlates with Defects in mtDNA Replication in Animal Cells

The mitochondrial single-stranded DNA-binding protein (mtSSB) is believed to coordinate the functions of DNA polymerase γ (pol γ) and the mitochondrial DNA (mtDNA) helicase at the mtDNA replication fork. We generated five variants of the human mtSSB bearing mutations in amino acid residues specific...

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Bibliographic Details
Main Authors: Oliveira, Marcos T., Kaguni, Laurie S.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
DNA and Chromosomes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220507/
https://ncbi.nlm.nih.gov/pubmed/21953457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.289983
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