MUSCLE-SPECIFIC OVEREXPRESSION OF THE CATALYTIC SUBUNIT OF DNA POLYMERASE γ INDUCES PUPAL LETHALITY IN Drosophila melanogaster

We show the physiological effects and molecular characterization of overexpression of the catalytic core of mitochondrial DNA (mtDNA) polymerase (pol γ-α) in muscle of Drosophila melanogaster. Muscle-specific overexpression of pol γ-α using the UAS/GAL4 (where UAS is upstream activation sequence) sy...

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Detalhes bibliográficos
Publicado no:Arch Insect Biochem Physiol
Main Authors: Martínez-Azorín, Francisco, Calleja, Manuel, Hernández-Sierra, Rosana, Farr, Carol L., Kaguni, Laurie S., Garesse, Rafael
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703106/
https://ncbi.nlm.nih.gov/pubmed/23729397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/arch.21101
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