The accessory subunit of DNA polymerase γ is essential for mitochondrial DNA maintenance and development in Drosophila melanogaster

DNA polymerase γ, Pol γ, is the key replicative enzyme in animal mitochondria. The Drosophila enzyme is a heterodimer comprising catalytic and accessory subunits of 125 kDa and 35 kDa, respectively. Both subunits have been cloned and characterized in a variety of model systems, and genetic mutants o...

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Bibliographic Details
Main Authors: Iyengar, Balaji, Luo, Ningguang, Farr, Carol L., Kaguni, Laurie S., Campos, Ana Regina
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2002
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC123674/
https://ncbi.nlm.nih.gov/pubmed/11917141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.072664899
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