Inhibiting DNA methylation switches adipogenesis to osteoblastogenesis by activating Wnt10a

Both adipocytes and osteoblasts share the mesodermal lineage that derives from mesenchymal stem cells. Most studies investigating the mechanisms underlying the regulation of adipogenic or osteoblastogenic development focus on transcriptional pathways; little is known about the epigenetic mechanisms...

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Udgivet i:Sci Rep
Main Authors: Chen, Yii-Shyuan, Wu, Rui, Yang, Xiaosong, Kou, Shuping, MacDougald, Ormond A., Yu, Liqing, Shi, Hang, Xue, Bingzhong
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4853709/
https://ncbi.nlm.nih.gov/pubmed/27136753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep25283
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