Wnt6, Wnt10a and Wnt10b inhibit adipogenesis and stimulate osteoblastogenesis through a β-catenin-dependent mechanism

Wnt10b is an established regulator of mesenchymal stem cell (MSC) fate that inhibits adipogenesis and stimulates osteoblastogenesis, thereby impacting bone mass in vivo. However, downstream mechanisms through which Wnt10b exerts these effects are poorly understood. Moreover, whether other endogenous...

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Main Authors: Cawthorn, William P., Bree, Adam J., Yao, Yao, Du, Baowen, Hemati, Nahid, Martinez-Santibañez, Gabriel, MacDougald, Ormond A.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3261372/
https://ncbi.nlm.nih.gov/pubmed/21872687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2011.08.010
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