Wnt6, Wnt10a and Wnt10b inhibit adipogenesis and stimulate osteoblastogenesis through a β-catenin-dependent mechanism

Wnt10b is an established regulator of mesenchymal stem cell (MSC) fate that inhibits adipogenesis and stimulates osteoblastogenesis, thereby impacting bone mass in vivo. However, downstream mechanisms through which Wnt10b exerts these effects are poorly understood. Moreover, whether other endogenous...

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Bibliographic Details
Main Authors: Cawthorn, William P., Bree, Adam J., Yao, Yao, Du, Baowen, Hemati, Nahid, Martinez-Santibañez, Gabriel, MacDougald, Ormond A.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3261372/
https://ncbi.nlm.nih.gov/pubmed/21872687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2011.08.010
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