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Genetic Inhibition of PPARγ S112 Phosphorylation Reduces Bone Formation and Stimulates Marrow Adipogenesis()
A common feature of many skeletal diseases is the accumulation of marrow fat. A reciprocal relationship exists between osteogenesis and adipogenesis in bone marrow that is mediated by the relative activity of PPARγ and RUNX2 transcription factors. The ERK/MAPK pathway is an important inducer of MSC...
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| Publicado no: | Bone |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5743762/ https://ncbi.nlm.nih.gov/pubmed/29107124 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2017.10.023 |
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