Wnt6, Wnt10a and Wnt10b inhibit adipogenesis and stimulate osteoblastogenesis through a β-catenin-dependent mechanism

Wnt10b is an established regulator of mesenchymal stem cell (MSC) fate that inhibits adipogenesis and stimulates osteoblastogenesis, thereby impacting bone mass in vivo. However, downstream mechanisms through which Wnt10b exerts these effects are poorly understood. Moreover, whether other endogenous...

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Библиографические подробности
Главные авторы: Cawthorn, William P., Bree, Adam J., Yao, Yao, Du, Baowen, Hemati, Nahid, Martinez-Santibañez, Gabriel, MacDougald, Ormond A.
Формат: Artigo
Язык:Inglês
Опубликовано: 2011
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3261372/
https://ncbi.nlm.nih.gov/pubmed/21872687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2011.08.010
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