Oxidized LDL induces FAK-dependent RSK signaling to drive NF-κB activation and VCAM-1 expression

Oxidized low-density lipoprotein (oxLDL) accumulates early in atherosclerosis and promotes endothelial nuclear factor κB (NF-κB) activation, proinflammatory gene expression and monocyte adhesion. Like for other atherogenic factors, oxLDL-induced proinflammatory responses requires integrin-dependent...

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Vydáno v:J Cell Sci
Hlavní autoři: Yurdagul, Arif, Sulzmaier, Florian J., Chen, Xiao L., Pattillo, Christopher B., Schlaepfer, David D., Orr, A. Wayne
Médium: Artigo
Jazyk:Inglês
Vydáno: The Company of Biologists Ltd 2016
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4852771/
https://ncbi.nlm.nih.gov/pubmed/26906414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.182097
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