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FAK in cancer: mechanistic findings and clinical applications
Focal adhesion kinase (FAK) is a cytoplasmic protein tyrosine kinase that is over-expressed and activated in several advanced-stage solid cancers. FAK promotes tumor progression and metastasis through effects on cancer cells, as well as stromal cells of the tumor microenvironment. FAK’s kinase-depen...
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| Publicado no: | Nat Rev Cancer |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4365862/ https://ncbi.nlm.nih.gov/pubmed/25098269 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrc3792 |
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