FAK inhibition disrupts a β5 integrin signaling axis controlling anchorage-independent ovarian carcinoma growth

Ovarian cancer ascites fluid contains matrix proteins that can impact tumor growth via integrin receptor binding. In human ovarian tumor tissue arrays, we find that activation of the cytoplasmic focal adhesion (FAK) tyrosine kinase parallels increased tumor stage, β5 integrin, and osteopontin (OPN)...

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Detaylı Bibliyografya
Asıl Yazarlar: Tancioni, Isabelle, Uryu, Sean, Sulzmaier, Florian J., Shah, Nina R., Lawson, Christine, Miller, Nichol L.G., Jean, Christine, Chen, Xiao Lei, Ward, Kristy K., Schlaepfer, David D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4126870/
https://ncbi.nlm.nih.gov/pubmed/24899686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-13-1063
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