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Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function
Pharmacological focal adhesion kinase (FAK) inhibition prevents tumor growth and metastasis, via actions on both tumor and stromal cells. In this paper, we show that vascular endothelial cadherin (VEC) tyrosine (Y) 658 is a target of FAK in tumor-associated endothelial cells (ECs). Conditional kinas...
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| Main Authors: | , , , , , , , , , , , , , , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
The Rockefeller University Press
2014
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3897185/ https://ncbi.nlm.nih.gov/pubmed/24446483 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201307067 |
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