Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function

Pharmacological focal adhesion kinase (FAK) inhibition prevents tumor growth and metastasis, via actions on both tumor and stromal cells. In this paper, we show that vascular endothelial cadherin (VEC) tyrosine (Y) 658 is a target of FAK in tumor-associated endothelial cells (ECs). Conditional kinas...

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Main Authors: Jean, Christine, Chen, Xiao Lei, Nam, Ju-Ock, Tancioni, Isabelle, Uryu, Sean, Lawson, Christine, Ward, Kristy K., Walsh, Colin T., Miller, Nichol L.G., Ghassemian, Majid, Turowski, Patric, Dejana, Elisabetta, Weis, Sara, Cheresh, David A., Schlaepfer, David D.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Rockefeller University Press 2014
Ábhair:
Research Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3897185/
https://ncbi.nlm.nih.gov/pubmed/24446483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201307067
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