Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function

Pharmacological focal adhesion kinase (FAK) inhibition prevents tumor growth and metastasis, via actions on both tumor and stromal cells. In this paper, we show that vascular endothelial cadherin (VEC) tyrosine (Y) 658 is a target of FAK in tumor-associated endothelial cells (ECs). Conditional kinas...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Jean, Christine, Chen, Xiao Lei, Nam, Ju-Ock, Tancioni, Isabelle, Uryu, Sean, Lawson, Christine, Ward, Kristy K., Walsh, Colin T., Miller, Nichol L.G., Ghassemian, Majid, Turowski, Patric, Dejana, Elisabetta, Weis, Sara, Cheresh, David A., Schlaepfer, David D.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2014
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3897185/
https://ncbi.nlm.nih.gov/pubmed/24446483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201307067
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars