Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function

Pharmacological focal adhesion kinase (FAK) inhibition prevents tumor growth and metastasis, via actions on both tumor and stromal cells. In this paper, we show that vascular endothelial cadherin (VEC) tyrosine (Y) 658 is a target of FAK in tumor-associated endothelial cells (ECs). Conditional kinas...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Jean, Christine, Chen, Xiao Lei, Nam, Ju-Ock, Tancioni, Isabelle, Uryu, Sean, Lawson, Christine, Ward, Kristy K., Walsh, Colin T., Miller, Nichol L.G., Ghassemian, Majid, Turowski, Patric, Dejana, Elisabetta, Weis, Sara, Cheresh, David A., Schlaepfer, David D.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The Rockefeller University Press 2014
Gaiak:
Research Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3897185/
https://ncbi.nlm.nih.gov/pubmed/24446483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201307067
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