Inhibition of focal adhesion kinase (FAK) activity prevents anchorage-independent ovarian carcinoma cell growth and tumor progression

Recurrence and spread of ovarian cancer is the 5th leading cause of death for women in the United States. Focal adhesion kinase (FAK) is a cytoplasmic protein-tyrosine kinase located on chromosome 8q24.3 (gene is Ptk2), a site commonly amplified in serous ovarian cancer. Elevated FAK mRNA levels in...

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Bibliografiske detaljer
Main Authors: Ward, Kristy K., Tancioni, Isabelle, Lawson, Christine, Miller, Nichol L.G., Jean, Christine, Chen, Xiao Lei, Uryu, Sean, Kim, Josephine, Tarin, David, Stupack, Dwayne G., Plaxe, Steven C., Schlaepfer, David D.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3622195/
https://ncbi.nlm.nih.gov/pubmed/23275034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10585-012-9562-5
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