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A non-canonical role for Rgnef in promoting integrin-stimulated focal adhesion kinase activation

Rgnef (also known as p190RhoGEF or ARHGEF28) is a Rho guanine-nucleotide-exchange factor (GEF) that binds focal adhesion kinase (FAK). FAK is recruited to adhesions and activated by integrin receptors binding to matrix proteins, such as fibronectin (FN). Canonical models place Rgnef downstream of in...

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Podrobná bibliografie
Hlavní autoři: Miller, Nichol L. G., Lawson, Christine, Kleinschmidt, Elizabeth G., Tancioni, Isabelle, Uryu, Sean, Schlaepfer, David D.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Company of Biologists 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3820247/
https://ncbi.nlm.nih.gov/pubmed/24006257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.135509
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