FAK inhibition disrupts a β5 integrin signaling axis controlling anchorage-independent ovarian carcinoma growth

Ovarian cancer ascites fluid contains matrix proteins that can impact tumor growth via integrin receptor binding. In human ovarian tumor tissue arrays, we find that activation of the cytoplasmic focal adhesion (FAK) tyrosine kinase parallels increased tumor stage, β5 integrin, and osteopontin (OPN)...

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Main Authors: Tancioni, Isabelle, Uryu, Sean, Sulzmaier, Florian J., Shah, Nina R., Lawson, Christine, Miller, Nichol L.G., Jean, Christine, Chen, Xiao Lei, Ward, Kristy K., Schlaepfer, David D.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4126870/
https://ncbi.nlm.nih.gov/pubmed/24899686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-13-1063
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