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Recruitment of the adaptor protein Nck to PECAM-1 couples oxidant stress to canonical NF-κB signaling and inflammation

Oxidant stress drives nuclear factor κB (NF-κB) activation and NF-κB-dependent proinflammatory gene expression in endothelial cells during several pathological conditions, including ischemia/reperfusion injury. We showed that the Nck family of adaptor proteins linked tyrosine kinase signaling to oxi...

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Publicado en:Sci Signal
Autores principales: Chen, Jie, Leskov, Igor L., Yurdagul, Arif, Thiel, Bonnie, Kevil, Christopher G., Stokes, Karen Y., Orr, A. Wayne
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4413941/
https://ncbi.nlm.nih.gov/pubmed/25714462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2005648
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