Bithionol Potently Inhibits Human Soluble Adenylyl Cyclase through Binding to the Allosteric Activator Site

The signaling molecule cAMP regulates functions ranging from bacterial transcription to mammalian memory. In mammals, cAMP is synthesized by nine transmembrane adenylyl cyclases (ACs) and one soluble AC (sAC). Despite similarities in their catalytic domains, these ACs differ in regulation. Transmemb...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Kleinboelting, Silke, Ramos-Espiritu, Lavoisier, Buck, Hannes, Colis, Laureen, van den Heuvel, Joop, Glickman, J. Fraser, Levin, Lonny R., Buck, Jochen, Steegborn, Clemens
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2016
Ämnen:
Enzymology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4850313/
https://ncbi.nlm.nih.gov/pubmed/26961873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.708255
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