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Structure-Based Development of Novel Adenylyl Cyclase Inhibitors
In mammals, the second messenger cAMP is synthesized by a family of transmembrane isoforms (tmACs) and one known cytoplasmic enzyme, “soluble” adenylyl cyclase (sAC). Understanding the individual contributions of these families to cAMP signaling requires tools which can distinguish them. Here, we de...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3082441/ https://ncbi.nlm.nih.gov/pubmed/18630896 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800481q |
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