Bithionol Potently Inhibits Human Soluble Adenylyl Cyclase through Binding to the Allosteric Activator Site

The signaling molecule cAMP regulates functions ranging from bacterial transcription to mammalian memory. In mammals, cAMP is synthesized by nine transmembrane adenylyl cyclases (ACs) and one soluble AC (sAC). Despite similarities in their catalytic domains, these ACs differ in regulation. Transmemb...

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Vydáno v:J Biol Chem
Hlavní autoři: Kleinboelting, Silke, Ramos-Espiritu, Lavoisier, Buck, Hannes, Colis, Laureen, van den Heuvel, Joop, Glickman, J. Fraser, Levin, Lonny R., Buck, Jochen, Steegborn, Clemens
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
Témata:
Enzymology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4850313/
https://ncbi.nlm.nih.gov/pubmed/26961873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.708255
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