Bithionol Potently Inhibits Human Soluble Adenylyl Cyclase through Binding to the Allosteric Activator Site

The signaling molecule cAMP regulates functions ranging from bacterial transcription to mammalian memory. In mammals, cAMP is synthesized by nine transmembrane adenylyl cyclases (ACs) and one soluble AC (sAC). Despite similarities in their catalytic domains, these ACs differ in regulation. Transmemb...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Kleinboelting, Silke, Ramos-Espiritu, Lavoisier, Buck, Hannes, Colis, Laureen, van den Heuvel, Joop, Glickman, J. Fraser, Levin, Lonny R., Buck, Jochen, Steegborn, Clemens
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4850313/
https://ncbi.nlm.nih.gov/pubmed/26961873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.708255
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