Three-Dimensional QSAR Analysis and Design of New 1,2,4-Oxadiazole Antibacterials

The oxadiazole antibacterials, a class of newly discovered compounds that are active against Gram-positive bacteria, target bacterial cell-wall biosynthesis by inhibition of a family of essential enzymes, the penicillin-binding proteins. Ligand-based 3D-QSAR analyses by comparative molecular field a...

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Pubblicato in:Bioorg Med Chem Lett
Autori principali: Leemans, Erika, Mahasenan, Kiran V., Kumarasiri, Malika, Spink, Edward, Ding, Derong, O’Daniel, Peter, Boudreau, Marc A., Lastochkin, Elena, Testero, Sebastian A., Yamaguchi, Takao, Lee, Mijoon, Hesek, Dusan, Fisher, Jed F., Chang, Mayland, Mobashery, Shahriar
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4849414/
https://ncbi.nlm.nih.gov/pubmed/26733473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.12.041
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