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SAAFEC: Predicting the Effect of Single Point Mutations on Protein Folding Free Energy Using a Knowledge-Modified MM/PBSA Approach

Folding free energy is an important biophysical characteristic of proteins that reflects the overall stability of the 3D structure of macromolecules. Changes in the amino acid sequence, naturally occurring or made in vitro, may affect the stability of the corresponding protein and thus could be asso...

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Bibliografiske detaljer
Udgivet i:Int J Mol Sci
Main Authors: Getov, Ivan, Petukh, Marharyta, Alexov, Emil
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4848968/
https://ncbi.nlm.nih.gov/pubmed/27070572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms17040512
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