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Predicting protein–DNA binding free energy change upon missense mutations using modified MM/PBSA approach: SAMPDI webserver

MOTIVATION: Protein–DNA interactions are essential for regulating many cellular processes, such as transcription, replication, recombination and translation. Amino acid mutations occurring in DNA-binding proteins have profound effects on protein–DNA binding and are linked with many diseases. Hence,...

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Veröffentlicht in:Bioinformatics
Hauptverfasser: Peng, Yunhui, Sun, Lexuan, Jia, Zhe, Li, Lin, Alexov, Emil
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6048991/
https://ncbi.nlm.nih.gov/pubmed/29091991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btx698
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