Excision of Reprogramming Transgenes Improves the Differentiation Potential of iPS Cells Generated with a Single Excisable Vector

The residual presence of integrated transgenes following the derivation of induced pluripotent stem (iPS) cells is highly undesirable. Here we demonstrate efficient derivation of iPS cells free of exogenous reprogramming transgenes using an excisable polycistronic lentiviral vector. A novel version...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Stem Cells
Prif Awduron: Sommer, Cesar A., Sommer, Andreia Gianotti, Longmire, Tyler A., Christodoulou, Constantina, Thomas, Dolly D., Gostissa, Monica, Alt, Fred W., Murphy, George J., Kotton, Darrell N., Mostoslavsky, Gustavo
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2010
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4848036/
https://ncbi.nlm.nih.gov/pubmed/19904830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.255
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