Excision of Reprogramming Transgenes Improves the Differentiation Potential of iPS Cells Generated with a Single Excisable Vector

The residual presence of integrated transgenes following the derivation of induced pluripotent stem (iPS) cells is highly undesirable. Here we demonstrate efficient derivation of iPS cells free of exogenous reprogramming transgenes using an excisable polycistronic lentiviral vector. A novel version...

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Bibliografiset tiedot
Julkaisussa:Stem Cells
Päätekijät: Sommer, Cesar A., Sommer, Andreia Gianotti, Longmire, Tyler A., Christodoulou, Constantina, Thomas, Dolly D., Gostissa, Monica, Alt, Fred W., Murphy, George J., Kotton, Darrell N., Mostoslavsky, Gustavo
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2010
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4848036/
https://ncbi.nlm.nih.gov/pubmed/19904830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.255
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