Modeling APC mutagenesis and familial adenomatous polyposis using human iPS cells

Mutations in the gene Adenomatous Polyposis Coli or APC appear in most sporadic cases of colorectal cancer and it is the most frequent mutation causing hereditary Familial Adenomatous Polyposis. The detailed molecular mechanism by which APC mutations predispose to the development of colorectal cance...

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Vydáno v:PLoS One
Hlavní autoři: Sommer, Cesar A., Capilla, Amalia, Molina-Estevez, Francisco J., Gianotti-Sommer, Andreia, Skvir, Nicholas, Caballero, Ignacio, Chowdhury, Sanjib, Mostoslavsky, Gustavo
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6053155/
https://ncbi.nlm.nih.gov/pubmed/30024920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0200657
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