Excision of Reprogramming Transgenes Improves the Differentiation Potential of iPS Cells Generated with a Single Excisable Vector

The residual presence of integrated transgenes following the derivation of induced pluripotent stem (iPS) cells is highly undesirable. Here we demonstrate efficient derivation of iPS cells free of exogenous reprogramming transgenes using an excisable polycistronic lentiviral vector. A novel version...

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Vydáno v:Stem Cells
Hlavní autoři: Sommer, Cesar A., Sommer, Andreia Gianotti, Longmire, Tyler A., Christodoulou, Constantina, Thomas, Dolly D., Gostissa, Monica, Alt, Fred W., Murphy, George J., Kotton, Darrell N., Mostoslavsky, Gustavo
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4848036/
https://ncbi.nlm.nih.gov/pubmed/19904830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.255
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