Excision of Reprogramming Transgenes Improves the Differentiation Potential of iPS Cells Generated with a Single Excisable Vector

The residual presence of integrated transgenes following the derivation of induced pluripotent stem (iPS) cells is highly undesirable. Here we demonstrate efficient derivation of iPS cells free of exogenous reprogramming transgenes using an excisable polycistronic lentiviral vector. A novel version...

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Detaylı Bibliyografya
Yayımlandı:Stem Cells
Asıl Yazarlar: Sommer, Cesar A., Sommer, Andreia Gianotti, Longmire, Tyler A., Christodoulou, Constantina, Thomas, Dolly D., Gostissa, Monica, Alt, Fred W., Murphy, George J., Kotton, Darrell N., Mostoslavsky, Gustavo
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2010
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4848036/
https://ncbi.nlm.nih.gov/pubmed/19904830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.255
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