High fat diet enhances stemness and tumorigenicity of intestinal progenitors

Little is known about how pro-obesity diets regulate tissue stem and progenitor cell function. Here we find that high fat diet (HFD)-induced obesity augments the numbers and function of Lgr5(+) intestinal stem-cells (ISCs) of the mammalian intestine. Mechanistically, HFD induces a robust peroxisome...

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Vydáno v:Nature
Hlavní autoři: Beyaz, Semir, Mana, Miyeko D., Roper, Jatin, Kedrin, Dmitriy, Saadatpour, Assieh, Hong, Sue-Jean, Bauer-Rowe, Khristian E., Xifaras, Michael E., Akkad, Adam, Arias, Erika, Pinello, Luca, Katz, Yarden, Shinagare, Shweta, Abu-Remaileh, Monther, Mihaylova, Maria M., Lamming, Dudley W., Dogum, Rizkullah, Guo, Guoji, Bell, George W., Selig, Martin, Nielsen, G. Petur, Gupta, Nitin, Ferrone, Cristina R., Deshpande, Vikram, Yuan, Guo-Cheng, Orkin, Stuart H., Sabatini, David M., Yilmaz, Ömer H.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4846772/
https://ncbi.nlm.nih.gov/pubmed/26935695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature17173
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