Reprogramming committed murine blood cells to induced hematopoietic stem cells with defined factors

Hematopoietic stem cells (HSCs) sustain blood formation throughout life and are the functional units of bone marrow transplantation. We show that transient expression of six transcription factors RUNX1T1, HLF, LMO2, PRDM5, PBX1, and ZFP37 imparts multi-lineage transplantation potential onto otherwis...

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Detalhes bibliográficos
Main Authors: Riddell, Jonah, Gazit, Roi, Garrison, Brian S., Guo, Guoji, Saadatpour, Assieh, Mandal, Pankaj K., Ebina, Wataru, Volchkov, Pavel, Yuan, Guo-Cheng, Orkin, Stuart H., Rossi, Derrick J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060823/
https://ncbi.nlm.nih.gov/pubmed/24766805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.04.006
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