The histone demethylase UTX regulates the lineage-specific epigenetic program of invariant natural killer T cells

Invariant natural killer T (iNKT) cells are innate-like lymphocytes that protect against infection, autoimmune disease and cancer. However, little is known about epigenetic regulation of iNKT cell development. Here, we show that the H3K27me3 histone demethylase UTX is an essential cell-intrinsic fac...

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Veröffentlicht in:Nat Immunol
Hauptverfasser: Beyaz, Semir, Kim, Ji Hyung, Pinello, Luca, Xifaras, Michael E., Hu, Yu, Huang, Jialiang, Kerenyi, Marc A., Das, Partha P., Barnitz, R. Anthony, Herault, Aurelie, Dogum, Rizkullah, Haining, W. Nicholas, Yilmaz, Ömer H., Passegue, Emmanuelle, Yuan, Guo-Cheng, Orkin, Stuart H., Winau, Florian
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5247321/
https://ncbi.nlm.nih.gov/pubmed/27992400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3644
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