The histone demethylase UTX regulates the lineage-specific epigenetic program of invariant natural killer T cells

Invariant natural killer T (iNKT) cells are innate-like lymphocytes that protect against infection, autoimmune disease and cancer. However, little is known about epigenetic regulation of iNKT cell development. Here, we show that the H3K27me3 histone demethylase UTX is an essential cell-intrinsic fac...

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Detalhes bibliográficos
Publicado no:Nat Immunol
Main Authors: Beyaz, Semir, Kim, Ji Hyung, Pinello, Luca, Xifaras, Michael E., Hu, Yu, Huang, Jialiang, Kerenyi, Marc A., Das, Partha P., Barnitz, R. Anthony, Herault, Aurelie, Dogum, Rizkullah, Haining, W. Nicholas, Yilmaz, Ömer H., Passegue, Emmanuelle, Yuan, Guo-Cheng, Orkin, Stuart H., Winau, Florian
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5247321/
https://ncbi.nlm.nih.gov/pubmed/27992400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3644
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