Huntingtin’s spherical solenoid structure enables polyglutamine tract-dependent modulation of its structure and function

The polyglutamine expansion in huntingtin protein causes Huntington’s disease. Here, we investigated structural and biochemical properties of huntingtin and the effect of the polyglutamine expansion using various biophysical experiments including circular dichroism, single-particle electron microsco...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Vijayvargia, Ravi, Epand, Raquel, Leitner, Alexander, Jung, Tae-Yang, Shin, Baehyun, Jung, Roy, Lloret, Alejandro, Singh Atwal, Randy, Lee, Hyeongseok, Lee, Jong-Min, Aebersold, Ruedi, Hebert, Hans, Song, Ji-Joon, Seong, Ihn Sik
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Biophysics and Structural Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4846397/
https://ncbi.nlm.nih.gov/pubmed/27003594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.11184
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