Huntingtin’s spherical solenoid structure enables polyglutamine tract-dependent modulation of its structure and function

The polyglutamine expansion in huntingtin protein causes Huntington’s disease. Here, we investigated structural and biochemical properties of huntingtin and the effect of the polyglutamine expansion using various biophysical experiments including circular dichroism, single-particle electron microsco...

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Détails bibliographiques
Publié dans:eLife
Auteurs principaux: Vijayvargia, Ravi, Epand, Raquel, Leitner, Alexander, Jung, Tae-Yang, Shin, Baehyun, Jung, Roy, Lloret, Alejandro, Singh Atwal, Randy, Lee, Hyeongseok, Lee, Jong-Min, Aebersold, Ruedi, Hebert, Hans, Song, Ji-Joon, Seong, Ihn Sik
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications, Ltd 2016
Sujets:
Biophysics and Structural Biology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4846397/
https://ncbi.nlm.nih.gov/pubmed/27003594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.11184
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