Sustaining the spindle assembly checkpoint to improve cancer therapy

To prevent chromosome segregation errors, the spindle assembly checkpoint (SAC) delays mitosis exit until proper spindle assembly. We found that the FCP1 phosphatase and its downstream target WEE1 kinase oppose the SAC, promoting mitosis exit despite malformed spindles. We further showed that target...

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Bibliografiske detaljer
Udgivet i:Mol Cell Oncol
Main Authors: Visconti, Roberta, Della Monica, Rosa, Grieco, Domenico
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2015
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4845201/
https://ncbi.nlm.nih.gov/pubmed/27308561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2015.1046583
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