Sustaining the spindle assembly checkpoint to improve cancer therapy

To prevent chromosome segregation errors, the spindle assembly checkpoint (SAC) delays mitosis exit until proper spindle assembly. We found that the FCP1 phosphatase and its downstream target WEE1 kinase oppose the SAC, promoting mitosis exit despite malformed spindles. We further showed that target...

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Publicado en:Mol Cell Oncol
Autores principales: Visconti, Roberta, Della Monica, Rosa, Grieco, Domenico
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4845201/
https://ncbi.nlm.nih.gov/pubmed/27308561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2015.1046583
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