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Cell cycle checkpoint in cancer: a therapeutically targetable double-edged sword

Major currently used anticancer therapeutics either directly damage DNA or target and upset basic cell division mechanisms like DNA replication and chromosome segregation. These insults elicit activation of cell cycle checkpoints, safeguard mechanisms that cells implement to correctly complete cell...

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Bibliografske podrobnosti
izdano v:J Exp Clin Cancer Res
Main Authors: Visconti, Roberta, Della Monica, Rosa, Grieco, Domenico
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5037895/
https://ncbi.nlm.nih.gov/pubmed/27670139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-016-0433-9
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