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Cell cycle checkpoint in cancer: a therapeutically targetable double-edged sword
Major currently used anticancer therapeutics either directly damage DNA or target and upset basic cell division mechanisms like DNA replication and chromosome segregation. These insults elicit activation of cell cycle checkpoints, safeguard mechanisms that cells implement to correctly complete cell...
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| Veröffentlicht in: | J Exp Clin Cancer Res |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5037895/ https://ncbi.nlm.nih.gov/pubmed/27670139 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-016-0433-9 |
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