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Cell cycle checkpoint in cancer: a therapeutically targetable double-edged sword

Major currently used anticancer therapeutics either directly damage DNA or target and upset basic cell division mechanisms like DNA replication and chromosome segregation. These insults elicit activation of cell cycle checkpoints, safeguard mechanisms that cells implement to correctly complete cell...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Exp Clin Cancer Res
Prif Awduron: Visconti, Roberta, Della Monica, Rosa, Grieco, Domenico
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5037895/
https://ncbi.nlm.nih.gov/pubmed/27670139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-016-0433-9
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