Sustaining the spindle assembly checkpoint to improve cancer therapy

To prevent chromosome segregation errors, the spindle assembly checkpoint (SAC) delays mitosis exit until proper spindle assembly. We found that the FCP1 phosphatase and its downstream target WEE1 kinase oppose the SAC, promoting mitosis exit despite malformed spindles. We further showed that target...

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Detaylı Bibliyografya
Yayımlandı:Mol Cell Oncol
Asıl Yazarlar: Visconti, Roberta, Della Monica, Rosa, Grieco, Domenico
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Taylor & Francis 2015
Konular:
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Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4845201/
https://ncbi.nlm.nih.gov/pubmed/27308561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2015.1046583
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