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Sustaining the spindle assembly checkpoint to improve cancer therapy
To prevent chromosome segregation errors, the spindle assembly checkpoint (SAC) delays mitosis exit until proper spindle assembly. We found that the FCP1 phosphatase and its downstream target WEE1 kinase oppose the SAC, promoting mitosis exit despite malformed spindles. We further showed that target...
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| Опубликовано в: : | Mol Cell Oncol |
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| Главные авторы: | , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Taylor & Francis
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4845201/ https://ncbi.nlm.nih.gov/pubmed/27308561 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2015.1046583 |
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