The Fcp1-Wee1-Cdk1 axis affects spindle assembly checkpoint robustness and sensitivity to antimicrotubule cancer drugs

To grant faithful chromosome segregation, the spindle assembly checkpoint (SAC) delays mitosis exit until mitotic spindle assembly. An exceedingly prolonged mitosis, however, promotes cell death and by this means antimicrotubule cancer drugs (AMCDs), that impair spindle assembly, are believed to kil...

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Publicat a:Cell Death Differ
Autors principals: Visconti, R, Della Monica, R, Palazzo, L, D'Alessio, F, Raia, M, Improta, S, Villa, M R, Del Vecchio, L, Grieco, D
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
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Original Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4532778/
https://ncbi.nlm.nih.gov/pubmed/25744022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2015.13
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