The Fcp1-Wee1-Cdk1 axis affects spindle assembly checkpoint robustness and sensitivity to antimicrotubule cancer drugs

To grant faithful chromosome segregation, the spindle assembly checkpoint (SAC) delays mitosis exit until mitotic spindle assembly. An exceedingly prolonged mitosis, however, promotes cell death and by this means antimicrotubule cancer drugs (AMCDs), that impair spindle assembly, are believed to kil...

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Vydáno v:Cell Death Differ
Hlavní autoři: Visconti, R, Della Monica, R, Palazzo, L, D'Alessio, F, Raia, M, Improta, S, Villa, M R, Del Vecchio, L, Grieco, D
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
Témata:
Original Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4532778/
https://ncbi.nlm.nih.gov/pubmed/25744022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2015.13
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