The Fcp1-Wee1-Cdk1 axis affects spindle assembly checkpoint robustness and sensitivity to antimicrotubule cancer drugs

To grant faithful chromosome segregation, the spindle assembly checkpoint (SAC) delays mitosis exit until mitotic spindle assembly. An exceedingly prolonged mitosis, however, promotes cell death and by this means antimicrotubule cancer drugs (AMCDs), that impair spindle assembly, are believed to kil...

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Bibliografske podrobnosti
izdano v:Cell Death Differ
Main Authors: Visconti, R, Della Monica, R, Palazzo, L, D'Alessio, F, Raia, M, Improta, S, Villa, M R, Del Vecchio, L, Grieco, D
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2015
Teme:
Original Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4532778/
https://ncbi.nlm.nih.gov/pubmed/25744022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2015.13
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