Transposon mutagenesis identifies genetic drivers of Braf(V600E) melanoma

Although nearly half of human melanomas harbor oncogenic BRAF(V600E) mutations, the genetic events that cooperate with these mutations to drive melanogenesis are still largely unknown. Here we show that Sleeping Beauty (SB) transposon-mediated mutagenesis drives melanoma progression in Braf(V600E) m...

詳細記述

保存先:
書誌詳細
出版年:Nat Genet
主要な著者: Mann, Michael B, Black, Michael A, Jones, Devin J, Ward, Jerrold M, Yew, Christopher Chin Kuan, Newberg, Justin Y, Dupuy, Adam J, Rust, Alistair G, Bosenberg, Marcus W, McMahon, Martin, Print, Cristin G, Copeland, Neal G, Jenkins, Nancy A
フォーマット: Artigo
言語:Inglês
出版事項: 2015
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4844184/
https://ncbi.nlm.nih.gov/pubmed/25848750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3275
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