Transposon mutagenesis identifies genetic drivers of Braf(V600E) melanoma

Although nearly half of human melanomas harbor oncogenic BRAF(V600E) mutations, the genetic events that cooperate with these mutations to drive melanogenesis are still largely unknown. Here we show that Sleeping Beauty (SB) transposon-mediated mutagenesis drives melanoma progression in Braf(V600E) m...

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Publicado en:Nat Genet
Main Authors: Mann, Michael B, Black, Michael A, Jones, Devin J, Ward, Jerrold M, Yew, Christopher Chin Kuan, Newberg, Justin Y, Dupuy, Adam J, Rust, Alistair G, Bosenberg, Marcus W, McMahon, Martin, Print, Cristin G, Copeland, Neal G, Jenkins, Nancy A
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4844184/
https://ncbi.nlm.nih.gov/pubmed/25848750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3275
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