Sleeping Beauty transposon mutagenesis identifies genes that cooperate with mutant Smad4 in gastric cancer development

Mutations in SMAD4 predispose to the development of gastrointestinal cancer, which is the third leading cause of cancer-related deaths. To identify genes driving gastric cancer (GC) development, we performed a Sleeping Beauty (SB) transposon mutagenesis screen in the stomach of Smad4(+/−) mutant mic...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Takeda, Haruna, Rust, Alistair G., Ward, Jerrold M., Yew, Christopher Chin Kuan, Jenkins, Nancy A., Copeland, Neal G.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833248/
https://ncbi.nlm.nih.gov/pubmed/27006499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1603223113
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