Transposon mutagenesis identifies genes that cooperate with mutant Pten in breast cancer progression

Triple-negative breast cancer (TNBC) has the worst prognosis of any breast cancer subtype. To better understand the genetic forces driving TNBC, we performed a transposon mutagenesis screen in a phosphatase and tensin homolog (Pten) mutant mice and identified 12 candidate trunk drivers and a much la...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Rangel, Roberto, Lee, Song-Choon, Hon-Kim Ban, Kenneth, Guzman-Rojas, Liliana, Mann, Michael B., Newberg, Justin Y., Kodama, Takahiro, McNoe, Leslie A., Selvanesan, Luxmanan, Ward, Jerrold M., Rust, Alistair G., Chin, Kuan-Yew, Black, Michael A., Jenkins, Nancy A., Copeland, Neal G.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5137755/
https://ncbi.nlm.nih.gov/pubmed/27849608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1613859113
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