Transposon mutagenesis identifies genes that transform neural stem cells into glioma-initiating cells

Neural stem cells (NSCs) are considered to be the cell of origin of glioblastoma multiforme (GBM). However, the genetic alterations that transform NSCs into glioma-initiating cells remain elusive. Using a unique transposon mutagenesis strategy that mutagenizes NSCs in culture, followed by additional...

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Autors principals: Koso, Hideto, Takeda, Haruna, Yew, Christopher Chin Kuan, Ward, Jerrold M., Nariai, Naoki, Ueno, Kazuko, Nagasaki, Masao, Watanabe, Sumiko, Rust, Alistair G., Adams, David J., Copeland, Neal G., Jenkins, Nancy A.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2012
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497753/
https://ncbi.nlm.nih.gov/pubmed/23045694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1215899109
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