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Differential AKT dependency displayed by mouse models of BRAF(V600E)-initiated melanoma
Malignant melanoma is frequently driven by mutational activation of v-raf murine sarcoma viral oncogene homolog B1 (BRAF) accompanied by silencing of the phosphatase and tensin homology (PTEN) tumor suppressor. Despite the implied importance of PI3K signaling in PTEN(Null) melanomas, mutational acti...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Clinical Investigation
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3859393/ https://ncbi.nlm.nih.gov/pubmed/24200692 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI69619 |
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