BRAF inhibitor resistance mediated by the AKT pathway in an oncogenic BRAF mouse melanoma model

BRAF (v-raf murine sarcoma viral oncogene homolog B) inhibitors elicit a transient anti-tumor response in ∼80% of BRAF(V600)-mutant melanoma patients that almost uniformly precedes the emergence of resistance. Here we used a mouse model of melanoma in which melanocyte-specific expression of Braf(V61...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Perna, Daniele, Karreth, Florian A., Rust, Alistair G., Perez-Mancera, Pedro A., Rashid, Mamunur, Iorio, Francesco, Alifrangis, Constantine, Arends, Mark J., Bosenberg, Marcus W., Bollag, Gideon, Tuveson, David A., Adams, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4330752/
https://ncbi.nlm.nih.gov/pubmed/25624498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1418163112
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados