Co-inhibition of colony stimulating factor-1 receptor and BRAF oncogene in mouse models of BRAF(V600E) melanoma

The presence of colony stimulating factor-1 (CSF1)/CSF1 receptor (CSF1R)-driven tumor-infiltrating macrophages and myeloid-derived suppressor cells (MDSCs) is shown to promote targeted therapy resistance. In this study, we demonstrate the superior effect of a combination of CSF1R inhibitor, PLX3397...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Ngiow, Shin Foong, Meeth, Katrina M., Stannard, Kimberley, Barkauskas, Deborah S., Bollag, Gideon, Bosenberg, Marcus, Smyth, Mark J.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
Assuntos:
MIATA Compliant Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4839378/
https://ncbi.nlm.nih.gov/pubmed/27141346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1089381
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