BRAF inhibitor resistance mediated by the AKT pathway in an oncogenic BRAF mouse melanoma model

BRAF (v-raf murine sarcoma viral oncogene homolog B) inhibitors elicit a transient anti-tumor response in ∼80% of BRAF(V600)-mutant melanoma patients that almost uniformly precedes the emergence of resistance. Here we used a mouse model of melanoma in which melanocyte-specific expression of Braf(V61...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Proc Natl Acad Sci U S A
मुख्य लेखकों: Perna, Daniele, Karreth, Florian A., Rust, Alistair G., Perez-Mancera, Pedro A., Rashid, Mamunur, Iorio, Francesco, Alifrangis, Constantine, Arends, Mark J., Bosenberg, Marcus W., Bollag, Gideon, Tuveson, David A., Adams, David J.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: National Academy of Sciences 2015
विषय:
PNAS Plus
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4330752/
https://ncbi.nlm.nih.gov/pubmed/25624498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1418163112
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